Heterogeneous IgG subclass distribution of islet cell antibodies.

  title={Heterogeneous IgG subclass distribution of islet cell antibodies.},
  author={Nicoletta Dozio and Cristina Belloni and Anna Maria Girardi and Stefano Genovese and J-Cl. Sodoyez and Gian Franco Bottazzo and Guido Pozza and Emanuele Bosi},
  journal={Journal of autoimmunity},
  volume={7 1},
Islet cell antibodies (ICA)-IgG are the serological marker of type 1 diabetes, an organ-specific autoimmune disease. A proportion of patients also have thyro-gastric autoimmunity, implying a broader humoral autoreactivity in these cases. In order to determine whether this is also reflected within islet cell antibodies (ICA) we examined the ICA-IgG subclass distribution in type 1 diabetic patients with or without associated thyro-gastric autoantibodies. ICA-IgG subclasses were detected by two… CONTINUE READING