Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favourable prognosis

@article{Pabst2009HeterogeneityWA,
  title={Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favourable prognosis},
  author={Thomas Pabst and Marianne Eyholzer and Jos{\'e} Fos and Beatrice U. Mueller},
  journal={British Journal of Cancer},
  year={2009},
  volume={100},
  pages={1343 - 1346}
}
CCAAT/enhancer binding protein alpha (CEBPA) mutations in AML are associated with favourable prognosis and are divided into N- and C-terminal mutations. The majority of AML patients have both types of mutations. We assessed the prognostic significance of single (n=7) and double (n=12) CEBPA mutations among 224 AML patients. Double CEBPA mutations conferred a decisively favourable overall (P=0.006) and disease-free survival (P=0.013). However, clinical outcome of patients with single CEBPA… CONTINUE READING