Heterogeneity of unfractionated heparins studied in connection with species, source, and production processes.

@article{Bianchini1997HeterogeneityOU,
  title={Heterogeneity of unfractionated heparins studied in connection with species, source, and production processes.},
  author={Pietro Bianchini and Lino Liverani and Giuseppe Mascellani and Bruna Parma},
  journal={Seminars in thrombosis and hemostasis},
  year={1997},
  volume={23 1},
  pages={
          3-10
        }
}
The heterogeneity of unfractionated heparins (Hep) can be correlated to the species and organs of origin and to the process of production. Heparins, extracted by different, validated processes from different organs and/or tissues (mucosa, thymus, pancreas, placenta, lung, intestine) or mammals (pig, beef, sheep, man) and other vertebrates (chicken), have been examined by HPLC analysis of heparinase digests. By analysis of disaccharides many observations have been made. Porcine mucosa heparin… 

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