Heterogeneity of transcription factor binding specificity models within and across cell lines.

@article{Sharmin2016HeterogeneityOT,
  title={Heterogeneity of transcription factor binding specificity models within and across cell lines.},
  author={Mahfuza Sharmin and H{\'e}ctor Corrada Bravo and Sridhar Hannenhalli},
  journal={Genome research},
  year={2016},
  volume={26 8},
  pages={1110-23}
}
Complex gene expression patterns are mediated by the binding of transcription factors (TFs) to specific genomic loci. The in vivo occupancy of a TF is, in large part, determined by the TF's DNA binding interaction partners, motivating genomic context-based models of TF occupancy. However, approaches thus far have assumed a uniform TF binding model to… CONTINUE READING