Heterogeneity of the antigenic site responsible for the induction of neutralizing antibodies in infectious bursal disease virus

Abstract

Using neutralizing monoclonal antibodies, three categories of escape mutants were selected from a stock of wild-type infectious bursal disease virus (IBDV). Additional mutants were found, where alterations coexisted in two or three of these epitopes. Although each group of mutants had a distinct reaction pattern with neutralizing monoclonal antibodies, all… (More)
DOI: 10.1007/BF01310671

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