Heterogeneity of the antigenic site responsible for the induction of neutralizing antibodies in infectious bursal disease virus

@article{ppling1991HeterogeneityOT,
  title={Heterogeneity of the antigenic site responsible for the induction of neutralizing antibodies in infectious bursal disease virus},
  author={Volker {\"O}ppling and Hermann M{\"u}ller and H. Becht},
  journal={Archives of Virology},
  year={1991},
  volume={119},
  pages={211-223}
}
Using neutralizing monoclonal antibodies, three categories of escape mutants were selected from a stock of wild-type infectious bursal disease virus (IBDV). Additional mutants were found, where alterations coexisted in two or three of these epitopes. Although each group of mutants had a distinct reaction pattern with neutralizing monoclonal antibodies, all types of mutants were neutralized by convalescent chicken sera to the same extent. In spite of the lack of homogeneity in these antigenic… CONTINUE READING