Heterogeneity of the action potential in isolated rat ventricular myocytes and tissue.

  title={Heterogeneity of the action potential in isolated rat ventricular myocytes and tissue.},
  author={Tokuko Watanabe and Leanne M D Delbridge and Jos{\'e} Omar Bustamante and T. F. Mcdonald},
  journal={Circulation research},
  volume={52 3},
The objectives of this study were to measure action potential parameters in enzyme-dissociated, adult rat ventricular myocytes stimulated at 1 Hz, to compare these measurements with those obtained from intact ventricular tissue, and to determine myocyte and tissue responses at stimulus frequencies between 0.1 and 5 Hz. Action potentials were characterized in terms of amplitude, overshoot, resting potential, duration at 25% and 75% repolarization (APD25, APD75), and Vmax. Based on statistical… CONTINUE READING


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