Heterogeneity of the Angiogenic Response Induced in Different Normal Adult Tissues by Vascular Permeability Factor/Vascular Endothelial Growth Factor

@article{Pettersson2000HeterogeneityOT,
  title={Heterogeneity of the Angiogenic Response Induced in Different Normal Adult Tissues by Vascular Permeability Factor/Vascular Endothelial Growth Factor},
  author={Anna Lindskoog Pettersson and Janice A. Nagy and Lawrence F. Brown and Christian Sundberg and Ellen S. Morgan and Steven J. Jungles and Robert E. Carter and Jos{\'e} Eduardo Krieger and Eleanor J. Manseau and Veronica Harvey and Isabelle A. Eckelhoefer and Dian Feng and Ann M. Dvorak and Richard c. Mulligan and Harold F. Dvorak},
  journal={Laboratory Investigation},
  year={2000},
  volume={80},
  pages={99-115}
}
Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) is an angiogenic cytokine with potential for the treatment of tissue ischemia. To investigate the properties of the new blood vessels induced by VPF/VEGF, we injected an adenoviral vector engineered to express murine VPF/VEGF164 into several normal tissues of adult nude mice or rats. A dose-dependent angiogenic response was induced in all tissues studied but was more intense and persisted longer (months) in skin and fat… CONTINUE READING