Heterogeneity of synthetic factor Xa inhibitors.

  title={Heterogeneity of synthetic factor Xa inhibitors.},
  author={Grigoris T. Gerotziafas and Meyer Michel Samama},
  journal={Current pharmaceutical design},
  volume={11 30},
Heparins and vitamin K antagonists are the landmarks of antithrombotic treatment. Both of them were discovered by serendipity; they are multi-targeted drugs and share several limitations. New molecules have been designed in order to be both more selective concerning their biological target and more homogeneous in their biochemical structure aiming at an improved benefit/risk ratio in the treatment of thrombotic disease. In this article, we will review the pharmacological characteristics of the… Expand
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  • Expert review of pharmacoeconomics & outcomes research
  • 2007
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