Heterogeneity of sodium-dependent excitatory amino acid uptake mechanisms in rat brain.

@article{Ferkany1986HeterogeneityOS,
  title={Heterogeneity of sodium-dependent excitatory amino acid uptake mechanisms in rat brain.},
  author={John W. Ferkany and Joseph T Coyle},
  journal={Journal of neuroscience research},
  year={1986},
  volume={16 3},
  pages={491-503}
}
The pharmacologic and kinetic characteristics of sodium-dependent uptake of [3H]L-glutamate, [3H]D-aspartate, and [3H]L-aspartate into crude synaptosomal preparations of rat corpus striatum and cerebellum have been examined in vitro. In cerebellum the apparent Kts and Vmax for the three excitatory amino acids were identical whereas in striatal synaptosomes, the Vmax for [3H]L-glutamate was 30% greater (P less than or equal to .001) than for [3H]D-aspartate and 50% greater (P less than or equal… CONTINUE READING

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