Heterogeneity of sickle-cell anemia based on a profile of hematological variables.

@article{Odenheimer1983HeterogeneityOS,
  title={Heterogeneity of sickle-cell anemia based on a profile of hematological variables.},
  author={Dan Odenheimer and Charles F Whitten and Donald L. Rucknagel and Sharada A. Sarnaik and Charles F. Sing},
  journal={American journal of human genetics},
  year={1983},
  volume={35 6},
  pages={1224-40}
}
Factors that influence the heterogeneity of the disease expression of sickle-cell anemia are not well understood. This study examines the ability of a profile of six hematological variables (HB, HCT, RBC, %Hb F, MCV, and %HBA2) to predict the severity of disease measured on 225 patients ranging from 0.2 to 18 years of age. Four subgroups of patients were identified separately in each sex using cluster analysis techniques. In each sex, mean hemoglobin concentration and percent Hb F increased… CONTINUE READING