Heterogeneity of serum tryptophan concentration and availability to the brain in patients with the chronic fatigue syndrome.

@article{Badawy2005HeterogeneityOS,
  title={Heterogeneity of serum tryptophan concentration and availability to the brain in patients with the chronic fatigue syndrome.},
  author={Abdulla A-B Badawy and Christopher J. Morgan and Meirion B. Llewelyn and Selwyn R J Albuquerque and Anne Farmer},
  journal={Journal of psychopharmacology},
  year={2005},
  volume={19 4},
  pages={385-91}
}
We assessed the serotonin status of patients with the chronic fatigue syndrome (CFS). Tryptophan (Trp) availability to the brain, expressed as the ratio of concentration of serum Trp to the sum of those of its five competitors (CAA), and other parameters of Trp disposition were compared in 23 patients with the CFS and 42 healthy controls. The serum [free Trp]/[CAA] ratio was 43% higher in CFS patients, due to a 48% higher [free Trp]. [Total Trp] was also significantly higher (by 19%) in CFS… CONTINUE READING