Heterogeneity of pulmonary endothelial cyclic nucleotide response to Pseudomonas aeruginosa ExoY infection.

@article{Morrow2015HeterogeneityOP,
  title={Heterogeneity of pulmonary endothelial cyclic nucleotide response to Pseudomonas aeruginosa ExoY infection.},
  author={Kelly A. Morrow and Roland Seifert and Volkhard Kaever and Andrea L. Britain and Sarah L. Sayner and Cristhiaan D. Ochoa and Eugene A. Cioffi and Dara W. Frank and Thomas C. Rich and Troy Stevens},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2015},
  volume={309 10},
  pages={L1199-207}
}
Here, we tested the hypothesis that a promiscuous bacterial cyclase synthesizes purine and pyrimidine cyclic nucleotides in the pulmonary endothelium. To test this hypothesis, pulmonary endothelial cells were infected with a strain of the Gram-negative bacterium Pseudomonas aeruginosa that introduces only exoenzyme Y (PA103 ΔexoUexoT::Tc pUCPexoY; ExoY(+)) via a type III secretion system. Purine and pyrimidine cyclic nucleotides were simultaneously detected using mass spectrometry. Pulmonary… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 65 references

PDE 7 A 1 hydrolyzes cCMP

  • M Monzel, M Kuhn, H Bahre, R Seifert, EH Schneider
  • FEBS Lett
  • 2014

PDE7A1 638 hydrolyzes cCMP

  • M Monzel, M Kuhn, H Bahre, R Seifert, EH. Schneider
  • FEBS Lett 588:
  • 2014
1 Excerpt

Similar Papers

Loading similar papers…