Heterogeneity of pluripotent marker gene expression in colonies generated in human iPS cell induction culture.

@article{Masaki2007HeterogeneityOP,
  title={Heterogeneity of pluripotent marker gene expression in colonies generated in human iPS cell induction culture.},
  author={Hideki Masaki and Tetsuya Ishikawa and Shunichi Takahashi and Masafumi Okumura and Noriko Sakai and Megumi Haga and Katsuya Kominami and Hideyuki Migita and F. M. S. Mcdonald and Fumiki Shimada and Kazuhiro Sakurada},
  journal={Stem cell research},
  year={2007},
  volume={1 2},
  pages={
          105-15
        }
}
Induction of pluripotent stem cells from human fibroblasts has been achieved by the ectopic expression of two different sets of four genes. However, the mechanism of the pluripotent stem cell induction has not been elucidated. Here we identified a marked heterogeneity in colonies generated by the four-gene (Oct3/4, Sox2, c-Myc, and Klf4) transduction method in human neonatal skin-derived cells. The four-gene transduction gave a higher probability of induction for archetypal pluripotent stem… CONTINUE READING
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