Heterogeneity of plasma von Willebrand factor multimers resulting from proteolysis of the constituent subunit.

@article{Dent1991HeterogeneityOP,
  title={Heterogeneity of plasma von Willebrand factor multimers resulting from proteolysis of the constituent subunit.},
  author={Judith A. Dent and Miriam Galbusera and Zaverio M. Ruggeri},
  journal={The Journal of clinical investigation},
  year={1991},
  volume={88 3},
  pages={774-82}
}
In this report we demonstrate that proteolytic cleavage of the constituent subunit is one of the causes determining the heterogeneous size distribution of plasma von Willebrand factor (vWf) multimers. As shown by two-dimensional nonreduced/reduced agarose/polyacrylamide gel electrophoresis, the structure of circulating vWf molecules may deviate from that represented by assemblage of a variable number of identical subunits. Indeed, even though the largest multimers in normal plasma appear to be… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 72 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 28 references

Distinct abnormalities in the interaction of purified IIA and IIB von Willebrand factor with the two platelet binding sites GP Ib - IX and GP Ilb - Illa

D. Ginsburg, B. A. Konkle, +4 authors A. Y. Yang
J . Clin . Invest . • 1990

Molecular basis of human von Willebrand disease : analysis of platelet von Willebrand factor mRNA

S. B. Williams, L. P. McKeown, +3 authors M. E. Rick
Proc . Nati . Acad . Sci . USA . • 1989

Isola - tion and characterization of two domains of human von Willebrand factor that interact with fibrillar collagen Types I and III

L. J. Fretto, K. K. Hamilton, H. P. Erickson, P. A. McKee
J . Biol . Chem . • 1987

von Willebrand ' s disease Type IIC with different abnormalities of von Willebrand factor in the same sibship

S. D. Berkowitz, J. R. Roberts, +4 authors T. S. Zimmerman
Am . J . Hematol . • 1987

Similar Papers

Loading similar papers…