Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination

@article{Lucchinetti2000HeterogeneityOM,
  title={Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination},
  author={Claudia F. Lucchinetti and Wolfgang Br{\"u}ck and Joseph E. Parisi and Bernd Scheithauer and Moses Rodriguez and Hans Lassmann},
  journal={Annals of Neurology},
  year={2000},
  volume={47}
}
Multiple sclerosis (MS) is a disease with profound heterogeneity in clinical course, neuroradiological appearance of the lesions, involvement of susceptibility gene loci, and response to therapy. [] Key Method From a large pathology sample of MS, collected in three international centers, we selected 51 biopsies and 32 autopsies that contained actively demyelinating lesions defined by stringent criteria.

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