Heterogeneity of microbubble accumulation: a novel approach to discriminate between well-differentiated hepatocellular carcinomas and regenerative nodules.

@article{Maruyama2012HeterogeneityOM,
  title={Heterogeneity of microbubble accumulation: a novel approach to discriminate between well-differentiated hepatocellular carcinomas and regenerative nodules.},
  author={Hitoshi Maruyama and Masanori P. Takahashi and Tadashi Sekimoto and Hidehiro Kamesaki and T. Shimada and Fumihiko Kanai and Osamu Yokosuka},
  journal={Ultrasound in medicine & biology},
  year={2012},
  volume={38 3},
  pages={383-8}
}
This prospective study aimed to elucidate the possibility of differentiating well-differentiated hepatocellular carcinoma (wHCC) from regenerative nodule (RN) on the basis of the heterogeneity of microbubble accumulation. Intensity analysis was conducted on early-phase and late-phase (60 s and 900 s post-injection; perflubutane microbubble) harmonic sonograms in 33 focal hepatic lesions (≤ 15 mm; 30 patients with chronic liver disease) that were histologically proven as wHCC or RN… CONTINUE READING