Heterogeneity of malignant cells from a human colonic carcinoma.

  title={Heterogeneity of malignant cells from a human colonic carcinoma.},
  author={Michael G. Brattain and W D Fine and F M Khaled and J Thompson and D. E. Brattain},
  journal={Cancer research},
  volume={41 5},
Three subpopulations of malignant cells were isolated from a primary cell culture of a single human colonic carcinoma. The variant cells were established as cell lines designated HCT 116, HCT 116a, and HCT 116b, respectively. In vitro characterizations of the variant lines included growth in 0.5% agarose and growth on confluent layers of mouse fibroblasts. HCT 116a showed the highest colony formation in agarose and on confluent fibroblasts, while colony formation by HCT 116 was higher than that… CONTINUE READING
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