Heterogeneity of human platelets. II. Functional evidence suggestive of young and old platelets.

@article{Karpatkin1969HeterogeneityOH,
  title={Heterogeneity of human platelets. II. Functional evidence suggestive of young and old platelets.},
  author={Simon Karpatkin},
  journal={The Journal of clinical investigation},
  year={1969},
  volume={48 6},
  pages={1083-7}
}
In the previous communication, suggestive evidence was presented for large-heavy platelets being "young" platelets and light-small platelets being "old" platelets. Large-heavy, light-small, and total human platelet populations were compared with respect to their platelet function. After addition of adenosine diphosphate (ADP), thrombin, or epinephrine, platelet aggregation time was 3.0-, 4.5-, and 3.3-fold shorter with large-heavy platelets compared with light-small platelets, and large-heavy… CONTINUE READING
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