Heterogeneity of human anti-pig natural antibodies cross-reactive with the Gal(alpha1,3)Galactose epitope.

@article{McMorrow1997HeterogeneityOH,
  title={Heterogeneity of human anti-pig natural antibodies cross-reactive with the Gal(alpha1,3)Galactose epitope.},
  author={Isabel M McMorrow and Christopher A Comrack and David H Sachs and Harout Dersimonian},
  journal={Transplantation},
  year={1997},
  volume={64 3},
  pages={501-10}
}
BACKGROUND The cell surface carbohydrate moiety, Gal(alpha1,3)Galactose (alphaGal), has been implicated as the major determinant recognized by more than 80% of human anti-porcine natural antibodies (NAb). An ELISA system was developed for the detection of this subpopulation of porcine cell-reactive NAb using synthetic alphaGal conjugated to bovine serum albumin. METHODS A screen of 95 human serum samples by this method demonstrated marked variability in the alphaGal reactivity of unrelated… CONTINUE READING

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