Heterogeneity of hippocampal GABA(A) receptors: regulation by corticosterone.

  title={Heterogeneity of hippocampal GABA(A) receptors: regulation by corticosterone.},
  author={Miles Orchinik and Steve S Carroll and Yong Hua Li and Bruce S. McEwen and Norman Weiland},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={21 1},
Chronic stressors produce changes in hippocampal neurochemistry, neuronal morphology, and hippocampal-dependent learning and memory processes. In rats, stress-induced changes in CA3 apical dendritic structure are mediated by corticosterone (CORT) acting, in part, on excitatory amino acid neurotransmission. CORT also alters GABA-mediated inhibitory neurotransmission, so the GABA(A) receptor system may also contribute to dendritic remodeling and other stress-related changes in hippocampal… CONTINUE READING