Heterogeneity of genetic alterations in prostate cancer: evidence of the complex nature of the disease.

@article{Nwosu2001HeterogeneityOG,
  title={Heterogeneity of genetic alterations in prostate cancer: evidence of the complex nature of the disease.},
  author={Veronica C. Nwosu and John C. Carpten and Jeffrey M. Trent and Rose Sheridan},
  journal={Human molecular genetics},
  year={2001},
  volume={10 20},
  pages={2313-8}
}
Prostate cancer is a complex, multifactorial disease with genetic and environmental factors involved in its etiology. The search for genetic determinants involved in the disease has proven to be challenging, in part because such complex diseases are often not amenable to characterization by linkage analysis and positional cloning as is the case for diseases with simple Mendelian genetic inheritance. Prostate cancer susceptibility loci that have been reported so far include HPC1 (1q24-q25), PCAP… CONTINUE READING