Heterogeneity of gene expression profiles in head and neck cancer.

  title={Heterogeneity of gene expression profiles in head and neck cancer.},
  author={Jimmy Pramana and Nuno Pimentel and Ingrid Hofland and L. F. A. Wessels and Marie-Louise F. van Velthuysen and Douwe Atsma and Coen R. N. Rasch and Michiel Wilhelmus Maria van den Brekel and Adrian C. Begg},
  journal={Head & neck},
  volume={29 12},
BACKGROUND Results of gene expression profiling studies from different institutes often lack consistency. This could be due to the use of different microarray platforms and protocols, or to intratumoral heterogeneity in mRNA expression. The aim of our study was to quantify intratumoral heterogeneity in head and neck cancer. METHODS Forty-four fresh frozen biopsies were taken from 22 patients, 2 per tumor. RNA was extracted, tested for quality, amplified, labeled, and hybridized to a 35k… CONTINUE READING

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