Heterogeneity of functional responses in differentiated myeloid cell lines reveals EPRO cells as a valid model of murine neutrophil functional activation.

@article{Gaines2005HeterogeneityOF,
  title={Heterogeneity of functional responses in differentiated myeloid cell lines reveals EPRO cells as a valid model of murine neutrophil functional activation.},
  author={Peter C. W. Gaines and Jeffrey Chi and Nancy Berliner},
  journal={Journal of leukocyte biology},
  year={2005},
  volume={77 5},
  pages={669-79}
}
Mature neutrophils display multiple functional responses upon activation that include chemotaxis, adhesion to and transmigration across endothelial cells, phagocytosis, and pathogen destruction via potent microbicidal enzymes and reactive oxygen species. We are using myeloid cell line models to investigate the signaling pathways that govern neutrophil functional activation. To facilitate these studies, we have performed a direct comparison of functional responses of human and murine myeloid… CONTINUE READING

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