Heterogeneity of effector phenotype for acute phase and memory influenza A virus-specific CTL.

@article{Jenkins2007HeterogeneityOE,
  title={Heterogeneity of effector phenotype for acute phase and memory influenza A virus-specific CTL.},
  author={Misty Rayna Jenkins and Katherine Kedzierska and Peter C. Doherty and Stephen John Turner},
  journal={Journal of immunology},
  year={2007},
  volume={179 1},
  pages={64-70}
}
Ag-specific, CD8+ CTLs clear influenza A viruses from the lung via granzyme (Gzm) and perforin-dependent mechanisms. Ex vivo analysis of perforin-Gzm mRNA profiles demonstrated substantial heterogeneity in patterns of effector mRNA transcription of CD8+ D(b)NP(366)- or D(b)PA(224)-specific CTL. The only difference between the two epitope-specific sets was apparent very early after infection with similar molecular profiles seen in peak primary and secondary responses and in long-term memory… CONTINUE READING