Heterogeneity of detergent-insoluble membranes from human intestine containing caveolin-1 and ganglioside G(M1).

@article{Badizadegan2000HeterogeneityOD,
  title={Heterogeneity of detergent-insoluble membranes from human intestine containing caveolin-1 and ganglioside G(M1).},
  author={Kamran Badizadegan and Bonny L. Dickinson and Heidi E. Wheeler and Richard S Blumberg and Randall K. Holmes and Wayne I Lencer},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2000},
  volume={278 6},
  pages={G895-904}
}
In intestinal epithelia, cholera and related toxins elicit a cAMP-dependent chloride secretory response fundamental to the pathogenesis of toxigenic diarrhea. We recently proposed that specificity of cholera toxin (CT) action in model intestinal epithelia may depend on the toxin's cell surface receptor ganglioside G(M1). Binding G(M1) enabled the toxin to elicit a response, but forcing the toxin to enter the cell by binding the closely related ganglioside G(D1a) rendered the toxin inactive. The… CONTINUE READING