Heterogeneity of cultured leukemic lymphoid progenitor cells from B cell precursor acute lymphoblastic leukemia (ALL) patients.

@article{Uckun1987HeterogeneityOC,
  title={Heterogeneity of cultured leukemic lymphoid progenitor cells from B cell precursor acute lymphoblastic leukemia (ALL) patients.},
  author={Fatih M. Uckun and John H. Kersey and Kazimiera J. Gajl-Peczalska and Nyla A. Heerema and Arthur J Provisor and Dieter Haag and Gail Gilchrist and Chang Won Song and Diane C. Arthur and Jennifer Roloff},
  journal={The Journal of clinical investigation},
  year={1987},
  volume={80 3},
  pages={639-46}
}
Colony assays were performed for 50 patients with B cell precursor acute lymphoblastic leukemia (ALL). Blast colony formation was observed for 33 patients, and the plating efficiency (PE) showed a marked interpatient variation, which indicates a pronounced biological heterogeneity at the level of leukemic progenitor cells. Notably, the mean PE of leukemic B cell precursors from patients with a pseudodiploid or near-diploid karyotype with structural chromosomal abnormalities (SCA) was… CONTINUE READING

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