Heterogeneity of circulating CD8 T-cells specific to islet, neo-antigen and virus in patients with type 1 diabetes mellitus

@article{Laban2018HeterogeneityOC,
  title={Heterogeneity of circulating CD8 T-cells specific to islet, neo-antigen and virus in patients with type 1 diabetes mellitus},
  author={S. Laban and Jessica S. Suwandi and Vincent van Unen and J. Pool and Joris Wesselius and T. H{\"o}llt and Nicola Pezzotti and A. Vilanova and B. Lelieveldt and B. Roep},
  journal={PLoS ONE},
  year={2018},
  volume={13}
}
Auto-reactive CD8 T-cells play an important role in the destruction of pancreatic β-cells resulting in type 1 diabetes (T1D). However, the phenotype of these auto-reactive cytolytic CD8 T-cells has not yet been extensively described. We used high-dimensional mass cytometry to phenotype autoantigen- (pre-proinsulin), neoantigen- (insulin-DRIP) and virus- (cytomegalovirus) reactive CD8 T-cells in peripheral blood mononuclear cells (PBMCs) of T1D patients. A panel of 33 monoclonal antibodies was… Expand
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