Corpus ID: 198972935

Heterogeneity of circulating CD 8 T-cells specific to islet , neo-antigen and virus in patients with type 1 diabetes mellitus

@inproceedings{Laban2018HeterogeneityOC,
  title={Heterogeneity of circulating CD 8 T-cells specific to islet , neo-antigen and virus in patients with type 1 diabetes mellitus},
  author={S. Laban and Jessica S. Suwandi and V. V. Unen and J. Pool and Joris Wesselius and T. H{\"o}llt and Nicola Pezzotti and A. Vilanova and B. Lelieveldt and Bart and O. Roep},
  year={2018}
}
Auto-reactive CD8 T-cells play an important role in the destruction of pancreatic β-cells resulting in type 1 diabetes (T1D). However, the phenotype of these auto-reactive cytolytic CD8 T-cells has not yet been extensively described. We used high-dimensional mass cytometry to phenotype autoantigen(pre-proinsulin), neoantigen(insulin-DRIP) and virus(cytomegalovirus) reactive CD8 T-cells in peripheral blood mononuclear cells (PBMCs) of T1D patients. A panel of 33 monoclonal antibodies was… Expand
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