Heterogeneity of channel density in inositol-1,4,5-trisphosphate-sensitive Ca2+ stores

@article{Hirose1994HeterogeneityOC,
  title={Heterogeneity of channel density in inositol-1,4,5-trisphosphate-sensitive Ca2+ stores},
  author={Kenzo Hirose and M Lino},
  journal={Nature},
  year={1994},
  volume={372},
  pages={791-794}
}
lNOSiTOL-l,4,5-trisphosphate (InsP3)-induced Ca2+ release is a key mechanism for intracellular Ca2+ mobilization1. The rate of Ca2+ release declines progressively with time until a higher concen-tration of InsP3 is added, which is referred to as the incremental detection mechanism2. Two hypotheses have been postulated to explain these complex kinetics: (1) Ca2+ stores consist of multiple compartments (quanta) with different sensitivities to InsP3 (refs 3-7), and (2) the rate of Ca2+ release is… CONTINUE READING

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