Heterogeneity of cerebral capillary flow in man and its consequences for estimation of blood-brain barrier permeability.

@article{Hertz1980HeterogeneityOC,
  title={Heterogeneity of cerebral capillary flow in man and its consequences for estimation of blood-brain barrier permeability.},
  author={Marianne M. Hertz and Olaf Bjarne Paulson},
  journal={The Journal of clinical investigation},
  year={1980},
  volume={65 5},
  pages={
          1145-51
        }
}
Blood-brain barrier permeability studies made in man using the indicator dilution method revealed that the extraction of the test substance increases during the upslope of the venous (outflow) dilution curve. The present study aimed to obviate the possibility that this could result from intravascular phenomena, such as interlaminar diffusion (the result of differences in molecular size) and erythrocyte carriage. Several reference substances were employed for the determination of the extraction… CONTINUE READING

References

Publications referenced by this paper.