Heterogeneity of cerebral beta-adrenoceptor binding sites in various vertebrate species.

@article{Nahorski1978HeterogeneityOC,
  title={Heterogeneity of cerebral beta-adrenoceptor binding sites in various vertebrate species.},
  author={Stefan R. Nahorski},
  journal={European journal of pharmacology},
  year={1978},
  volume={51 3},
  pages={199-209}
}
[3H]-Dihydroalprenolol ([3H]-DHA) binds to cerebral membranes of the frog, chick, rat, mouse, rabbit and human with a dissociation equilibrium constant (KD) of about 1 nM and displays binding characteristics indicative of an interaction with beta-adrenoceptors. However, the maximum number of specific binding sites labelled by this beta-adrenoceptor ligand varies substantially between the species with the chick and mouse having the highest, and the frog the lowest density. The structure… CONTINUE READING

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