Heterogeneity of calcium clock functions in dormant, dysrhythmically and rhythmically firing single pacemaker cells isolated from SA node.

@article{Kim2018HeterogeneityOC,
  title={Heterogeneity of calcium clock functions in dormant, dysrhythmically and rhythmically firing single pacemaker cells isolated from SA node.},
  author={Mary Shin Kim and Alexander V. Maltsev and Oliver J Monfredi and Larissa A. Maltseva and Ashley Wirth and Maria Cristina Florio and Kenta Tsutsui and Daniel R. Riordon and Sean P Parsons and Syevda Tagirova and Bruce D. Ziman and Michael D. Stern and Edward G. Lakatta and Victor A. Maltsev},
  journal={Cell calcium},
  year={2018},
  volume={74},
  pages={
          168-179
        }
}
Current understanding of how cardiac pacemaker cells operate is based mainly on studies in isolated single sinoatrial node cells (SANC), specifically those that rhythmically fire action potentials similar to the in vivo behavior of the intact sinoatrial node. However, only a small fraction of SANC exhibit rhythmic firing after isolation. Other SANC behaviors have not been studied. Here, for the first time, we studied all single cells isolated from the sinoatrial node of the guinea pig… CONTINUE READING
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