Heterogeneity of beta-adrenoreceptors in guinea pig alveolar type II cells.

@article{Das1987HeterogeneityOB,
  title={Heterogeneity of beta-adrenoreceptors in guinea pig alveolar type II cells.},
  author={Salil K. Das and Matthew O. Sikpi and Phil Skolnick},
  journal={Biochemical and biophysical research communications},
  year={1987},
  volume={142 3},
  pages={898-903}
}
[3H]Dihydroalprenolol ([3H]DHA) binding to guinea pig alveolar type II cell membrane revealed the presence of both high (KD = 0.38 nM) and low (KD = 4.2 nM) affinity beta-adrenoreceptors. The low affinity site had a higher binding capacity (Bmax = 245.6 fmol/mg protein) than the high affinity site (Bmax = 71.7 fmol/mg protein). Displacement of [3H]DHA by practolol, a selective beta 1 agent, confirmed the existence of two species of adrenoreceptors, corresponding to 21% high affinity (beta 1… CONTINUE READING