Heterogeneity of androgen receptor content in advanced prostate cancer.

  title={Heterogeneity of androgen receptor content in advanced prostate cancer.},
  author={Cristina Magi-Galluzzi and Xiaowei Xu and Lynn Hlatky and Philip Hahnfeldt and Irving Kaplan and P N Hsiao and Chawnshang Chang and Massimo F. Loda},
  journal={Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc},
  volume={10 8},
The principal mode of treatment of advanced (late stage) prostate cancer is androgen ablation. Although the response rate to hormonal ablation is high, relapse ultimately leading to death occurs in the majority of patients in remission from outgrowth of androgen-independent tumor cells. High-grade and high-stage cancers are more likely to progress to androgen independence. This study was undertaken to analyze the expression level of androgen receptor (AR) protein in prostatic carcinomas in… CONTINUE READING


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