Heterogeneity of aldosterone-producing adenomas revealed by a whole transcriptome analysis.

@article{Lenzini2007HeterogeneityOA,
  title={Heterogeneity of aldosterone-producing adenomas revealed by a whole transcriptome analysis.},
  author={Livia Lenzini and Teresa Maria Seccia and Enrico Aldighieri and Anna Sandra Belloni and Paolo Bernante and Luisa Giuliani and Gastone Giovanni Nussdorfer and Achille Cesare Pessina and Gian Paolo Rossi},
  journal={Hypertension},
  year={2007},
  volume={50 6},
  pages={1106-13}
}
Aldosterone-producing adenomas (APAs) are a common cause of arterial hypertension, but the underlying molecular mechanisms are unknown, although a transcriptional modulation of aldosterone synthase (CYP11B2) has been suggested. Aldosterone synthesis involves 2 main rate-limiting steps: cholesterol transport into mitochondria and CYP11B2 gene transcription. Evidence supports a role of Ca(2+)/calmodulin-dependent protein kinases (CAMKs) in the regulation of angiotensin II- and potassium… CONTINUE READING

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