Heterogeneity of T cell clones specific for a single indirect alloantigenic epitope (I-Ab/H-2Kd54-68) that mediate transplant rejection.

@article{Honjo2000HeterogeneityOT,
  title={Heterogeneity of T cell clones specific for a single indirect alloantigenic epitope (I-Ab/H-2Kd54-68) that mediate transplant rejection.},
  author={Kazuhito Honjo and Xiao yan Xu and R. Pat Bucy},
  journal={Transplantation},
  year={2000},
  volume={70 10},
  pages={1516-24}
}
BACKGROUND One of the complexities of solid organ allograft rejection is the inherent diversity of the specific T cell antigenic epitopes that participate in this response, including the role of direct alloantigen recognition and indirect recognition of donor-derived peptides in recipient antigen-presenting cells. To probe the role of distinct T cell receptor (TCR) avidity differences and the role of cytokine expression patterns of different effector T cells that may participate in allograft… CONTINUE READING

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