Heterogeneity of Release Probability, Facilitation, and Depletion at Central Synapses

  title={Heterogeneity of Release Probability, Facilitation, and Depletion at Central Synapses},
  author={Lynn E Dobrunz and Charles F. Stevens},
Previous studies of short-term plasticity in central nervous systems synapses have largely focused on average synaptic properties. In this study, we use recordings from putative single synaptic release sites in hippocampal slices to show that significant heterogeneity exists in facilitation and depletion among synapses. In particular, the amount of paired-pulse facilitation is inversely related to the initial release probability of the synapse. We also examined depletion at individual synapses… CONTINUE READING
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An evaluation of causes for paired pulse facilitation and EPSC variance in the CA 1 region of the unreliability of synaptic transmission

  • C. F. Stevens
  • Proc . Natl . Acad . Sci . USA
  • 1994
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Heteroge - aptic transmission in the hippocampus . Eur . J . Pharmacol . 193 , neous release properties of visualized individual hippocampal syn131 – 132 . apses

  • T. J. Sejnowski, C. F. Stevens
  • Neuron
  • 1997

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