Heterogeneity of Raft-type membrane microdomains associated with VP4, the rotavirus spike protein, in Caco-2 and MA 104 cells.

@article{Delmas2007HeterogeneityOR,
  title={Heterogeneity of Raft-type membrane microdomains associated with VP4, the rotavirus spike protein, in Caco-2 and MA 104 cells.},
  author={Olivier Delmas and Michelyne Breton and Catherine Sapin and Andr{\'e} Le Bivic and Odile Colard and Germain Trugnan},
  journal={Journal of virology},
  year={2007},
  volume={81 4},
  pages={1610-8}
}
Previous studies have shown that rotavirus virions, a major cause of infantile diarrhea, assemble within small intestinal enterocytes and are released at the apical pole without significant cell lysis. In contrast, for the poorly differentiated kidney epithelial MA 104 cells, which have been used extensively to study rotavirus assembly, it has been shown that rotavirus is released by cell lysis. The subsequent discovery that rotavirus particles associate with raft-type membrane microdomains… CONTINUE READING
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