Heterogeneity of Intestinal Tissue Eosinophils: Potential Considerations for Next-Generation Eosinophil-Targeting Strategies

@article{Masterson2021HeterogeneityOI,
  title={Heterogeneity of Intestinal Tissue Eosinophils: Potential Considerations for Next-Generation Eosinophil-Targeting Strategies},
  author={Joanne C. Masterson and Calies Menard-Katcher and Leigha D Larsen and Glenn T. Furuta and Lisa A. Spencer},
  journal={Cells},
  year={2021},
  volume={10}
}
Eosinophils are implicated in the pathophysiology of a spectrum of eosinophil-associated diseases, including gastrointestinal eosinophilic diseases (EGIDs). Biologics that target the IL-5 pathway and are intended to ablate eosinophils have proved beneficial in severe eosinophilic asthma and may offer promise in treating some endotypes of EGIDs. However, destructive effector functions of eosinophils are only one side of the coin; eosinophils also play important roles in immune and tissue… 

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References

SHOWING 1-10 OF 163 REFERENCES

The Cellular Functions of Eosinophils: Collegium Internationale Allergologicum (CIA) Update 2020

TLDR
Recent literature pointing to important roles for eosinophils in promoting immune defense, antibody production, activation of adipose tissue, and tissue remodeling and fibrosis is reviewed.

Eosinophils in the gastrointestinal tract and their role in the pathogenesis of major colorectal disorders

  • A. Loktionov
  • Biology, Medicine
    World journal of gastroenterology
  • 2019
TLDR
The author hypothesises that immune responses within colorectal mucus as well as ETosis exerted by both neutrophils and eosinophils on the both sides of the colonic epithelial barrier act as additional pathogenetic factors in IBD.

Microbial regulation of enteric eosinophils and its impact on tissue remodeling and Th2 immunity

TLDR
It is found that small intestinal eosinophilia was significantly greater in germ-free (GF) mice compared to specific pathogen free (SPF) controls, and this was associated with changes in the production of enteric signals that regulate eOSinophil attraction and survival, and was fully reversed by complex colonization.

Eosinophil Granule Proteins: Form and Function

TLDR
Key molecular aspects of these eosinophil-derived granule proteins in terms of structure-function relationships are reviewed to advance understanding of their roles in eos inophil cell biology, molecular biology, and immunobiology in health and disease.

Essential Mechanisms of Differential Activation of Eosinophils by IL-3 Compared to GM-CSF and IL-5.

TLDR
Investigations that have compared the effects of the three β-chain receptor cytokines (IL-5, GM-CSF and IL-3) on eosinophil biology focus on how IL- 3 differentially activates eOSinophils compared to IL-5 or GM- CSF.

Eosinophils in health and disease: the LIAR hypothesis

TLDR
It is suggested that accumulating tissue eosinophils are actually regulators of Local Immunity And/or Remodeling/Repair in both health and disease – the LIAR hypothesis.

Eosinophils may play regionally disparate roles in influencing IgA+ plasma cell numbers during large and small intestinal inflammation

TLDR
It is demonstrated for the first time that there are regional differences in the requirement of eosinophils for maintaining IgA+ cells between the large and small intestine, which are more pronounced during inflammation.

IL-5 Promotes Eosinophil Trafficking to the Esophagus1

TLDR
It is demonstrated that transgenic mice overexpressing IL-5 under the control of a T cell (CD2) or a small intestinal enterocyte (fatty acid-binding protein) promoter have markedly increased eosinophil numbers in the esophagus.

Fundamental signals that regulate eosinophil homing to the gastrointestinal tract.

TLDR
Investigations demonstrate eosinophil homing into the gastrointestinal tract during embryonic development occurring independently of viable intestinal flora and eotaxin is identified as the primary regulator of eos inophil gastrointestinal homing under homeostatic states, and may therefore have a fundamental role in innate immune responses.
...