Heterogeneity of CYP3A isoforms metabolizing erythromycin and cortisol

  title={Heterogeneity of CYP3A isoforms metabolizing erythromycin and cortisol},
  author={C. Hunt and P. Watkins and P. Saenger and G. Stave and N. Barlascini and C. Watlington and J. Wright and P. Guzelian},
  journal={Clinical Pharmacology & Therapeutics},
  • C. Hunt, P. Watkins, +5 authors P. Guzelian
  • Published 1992
  • Biology, Medicine
  • Clinical Pharmacology & Therapeutics
  • The N‐demethylation of erythromycin and 6β‐hydroxylation of Cortisol are both functions of the glucocorticoid‐inducible CYP3A in human liver microsomes. To determine whether 6β‐hydroxylation and erythromycin N‐demethylation are catalyzed by similar or distinct CYP3A isoforms, erythromycin N‐demethylase activity, as reflected by the recently described 14[C]‐erythromycin breath test, was compared with urinary 6β‐hydroxycortisol/cortisol ratios, a measure of Cortisol 6β‐hydroxylase activity, in… CONTINUE READING
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