Heterogeneity of B-lymphoid tumors in E mu-myc transgenic mice.

  title={Heterogeneity of B-lymphoid tumors in E mu-myc transgenic mice.},
  author={Vikram Prasad and Mike Temple and Muriel T. Davisson and E. C. Akeson and Charles L. Sidman},
  volume={23 2},
The clinically important issue of tumor heterogeneity was studied in C57BL/6-E mu-myc transgenic mice, which provide a genetically uniform model system in which all animals eventually develop B cell lymphomas after additional genetic changes beyond enforced expression of the transgenic oncogene. Three different approaches were compared for discerning the cellular and genetic homogeneity of these tumors. Analysis of Igh gene rearrangement showed mainly monoclonality and only infrequent… CONTINUE READING