Heterogeneity of 5 alpha-reductase gene expression in benign prostatic hyperplasia.

@article{Sherwood2003HeterogeneityO5,
  title={Heterogeneity of 5 alpha-reductase gene expression in benign prostatic hyperplasia.},
  author={Jennifer B. Sherwood and John D McConnell and Dolores J Vazquez and Vitor K Lin and Claus G. Roehrborn},
  journal={The Journal of urology},
  year={2003},
  volume={169 2},
  pages={575-9}
}
PURPOSE The search for molecular markers of benign prostatic hyperplasia in general is based on an analysis of a limited number of biopsy samples. Little is known about the homogeneity of the expression of key genes in different zones of the prostate. We studied the intraprostatic (that is within the same gland) and inter-prostatic (that is between glands) variability of 5 alpha-reductase 2 (5aR2) gene expression. MATERIALS AND METHODS Ten tissue samples removed by open prostatectomy were the… CONTINUE READING