Heterogeneity maintenance in glioblastoma: a social network.

  title={Heterogeneity maintenance in glioblastoma: a social network.},
  author={Rudy Bonavia and Mar{\'i}a-del-Mar Inda and Webster K Cavenee and Frank B Furnari},
  journal={Cancer research},
  volume={71 12},
Glioblastoma multiforme (GBM), the most common intracranial tumor in adults, is characterized by extensive heterogeneity at the cellular and molecular levels. This insidious feature arises inevitably in almost all cancers and has great significance for the general outcome of the malignancy, because it confounds our understanding of the disease and also intrinsically contributes to the tumor's aggressiveness and poses an obstacle to the design of effective therapies. The classic view that… CONTINUE READING