Heterogeneity in the modification and involvement of chromatin components of the CpG island of the silenced human CDH1 gene in cancer cells.

@article{Koizume2002HeterogeneityIT,
  title={Heterogeneity in the modification and involvement of chromatin components of the CpG island of the silenced human CDH1 gene in cancer cells.},
  author={Shiro Koizume and Ken Tachibana and Takao Sekiya and Setsuo Hirohashi and Masahiko Shiraishi},
  journal={Nucleic acids research},
  year={2002},
  volume={30 21},
  pages={4770-80}
}
The structural alteration of chromatin has a key role in regulating gene expression. The alteration of chromatin is mediated by modification of its components. Detailed understanding of the relationship between these modifications, notably, methylation of the full-length CpG island, the association of methyl-CpG binding proteins (MBPs), and the acetylation and methylation of histones in gene silencing is vitally important. Currently, however, the manner in which chromatin components, associated… CONTINUE READING
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