Heterogeneity in the mechanisms of vasorelaxation to anandamide in resistance and conduit rat mesenteric arteries.

@article{OSullivan2004HeterogeneityIT,
  title={Heterogeneity in the mechanisms of vasorelaxation to anandamide in resistance and conduit rat mesenteric arteries.},
  author={Saoirse Elizabeth O'Sullivan and David A. Kendall and Michael D Randall},
  journal={British journal of pharmacology},
  year={2004},
  volume={142 3},
  pages={435-42}
}
1 In order to address mechanistic differences between arterial vessel types, we have compared the vasorelaxant actions of anandamide in resistance (G3) and conduit (G0) mesenteric arteries. 2 Anandamide produced concentration-dependent relaxations of pre-constricted G3 arteries with a maximal response that was significantly greater than seen in G0. 3 The CB1 receptor selective antagonists SR141716A (100 nm) and AM251 (100 nm) caused reductions in the vasorelaxant responses to anandamide in both… CONTINUE READING

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