Heterogeneity in the actions of drugs that bind in the DNA minor groove.

@article{Albert1999HeterogeneityIT,
  title={Heterogeneity in the actions of drugs that bind in the DNA minor groove.},
  author={F G Albert and Todd T. Eckdahl and Daniel J. Fitzgerald and John N. Anderson},
  journal={Biochemistry},
  year={1999},
  volume={38 31},
  pages={10135-46}
}
Distamycin and Hoechst 33258 have long served as the model compounds for biochemical, biophysical, and clinical studies of the drugs that bind in the DNA minor groove. However, the results presented in this investigation clearly show that 4,6-diamidino-2 phenylindole (DAPI) is superior to both of these drugs at negating the effects of intrinsic DNA curvature and anisotropic bendability as measured by electrophoretic and ligation analysis. In addition, DAPI was more effective than distamycin and… CONTINUE READING