Heterogeneity in relaxation mechanisms in the carotid and the femoral artery of the mouse.

@article{Crauwels2000HeterogeneityIR,
  title={Heterogeneity in relaxation mechanisms in the carotid and the femoral artery of the mouse.},
  author={Herta M. Crauwels and Cor E. Van Hove and Arnold G. Herman and Hidde Bult},
  journal={European journal of pharmacology},
  year={2000},
  volume={404 3},
  pages={
          341-51
        }
}
The participation of prostanoids, nitric oxide and non-prostanoid non-nitric oxide factors in endothelium-dependent relaxations was investigated in phenylephrine (PE)-constricted carotid and femoral arteries of C57BL6 mice. The carotid artery was more sensitive to acetylcholine as compared to the femoral artery, and cyclooxygenase inhibition did not influence the relaxation in either vessel. In the carotid artery, high doses of acetylcholine caused transient constrictions, which were abolished… CONTINUE READING

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