Heterogeneity in in vitro response to progesterone and melphalan of mammary tumours induced in the rat by 7,12-DMBA.

Five mammary tumours induced in rats by 7, 12-DMBA were each divided into four sections, and studied as cell suspensions in vitro for response to melphalan or progesterone measured as H3-thymidine incorporation. Heterogeneity towards melphalan and progesterone was found within all five tumours, but the mode of reaction of the two drugs differed. The… CONTINUE READING