Heterogeneity in function of small artery smooth muscle BKCa: involvement of the beta1-subunit.

@article{Yang2009HeterogeneityIF,
  title={Heterogeneity in function of small artery smooth muscle BKCa: involvement of the beta1-subunit.},
  author={Yan Yang and Timothy V. Murphy and Srikanth R. Ella and T. Hilton Grayson and Rebecca E. Haddock and Yun Tae Hwang and Andrew P Braun and Gui Peichun and Ronald J. Korthuis and Michael J Davis and Michael A Hill},
  journal={The Journal of physiology},
  year={2009},
  volume={587 Pt 12},
  pages={3025-44}
}
Arteriolar myogenic vasoconstriction occurs when increased stretch or membrane tension leads to smooth muscle cell depolarization and opening of voltage-gated Ca2+ channels. To prevent positive feedback and excessive pressure-induced vasoconstriction, studies in cerebral artery smooth muscle have suggested that activation of large conductance, Ca2+-activated K+ channels (BKCa) provides an opposing hyperpolarizing influence reducing Ca2+ channel activity. We have hypothesized that this mechanism… CONTINUE READING
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